Ethanol is used in the management of toxicity due to ingestion of methanol, or ethylene glycol.

Ethanol is available under the following different brand and other names: alcohol (ethyl).

DOSAGES OF Ethanol

Adult and Pediatric Dosage Forms and Strengths

Injection solution (95%)

1 mL

5 mL

Dosage Considerations – Should be Given as Follows:

Methanol Toxicity, Ethylene Glycol Poisoning (Off-label)

Adult

Loading dose

600 mg/kg intravenous (IV) (i.e., 7.6 mL/kg of 10% EtOH solution)

600-700 mg/kg oral/nasogastric (NG) using a 95% solution diluted to 20% or less with water or juice

Maintenance dose

65-155 mg/kg/hour depending on alcohol consumption status (lower for nondrinker)

Oral maintenance = 0.15 mL/kg/hour (IV = 1.4 mL/kg/hour) 10% Ethanol

Chronic alcoholics and hemodialysis patients need increased dose; increased maintenance by 50%; non-users may need less

Maintain serum Ethanol of 100-150 mg/dL [21.7-32.55 mmol/L]

Pediatric

Reduce Ethanol loading dose if methanol or ethylene glycol ingested with alcohol

May need to increase Ethanol maintenance dose in patients with chronic alcohol consumption

Loading dose (oral)

95% EtOH: 0.8-1 mL/kg

40% EtOH (80 proof undiluted liquor): 2 mL/kg

43% EtOH (86 proof undiluted liquor): 1.8 mL/kg

Maintenance dose (oral)

43% EtOH: 0.1 mL/kg/hour

95% EtOH: 0.1 mL/kg/hour

Intravenous (IV) dose (10% EtOH)

10% EtOH = 7.9 g/dL

Loading: 8-10 mL/kg IV; not to exceed 200 mL

Maintenance: 0.83 mL/kg/hour intravenous (IV)

10% EtOH = 7.9 g/dL

40% EtOH (80 proof undiluted liquor) = 31.6 g/dL

43% EtOH (86% proof undiluted liquor) = 34 g/dL

95% EtOH (absolute alcohol) = 75 g/dL

Continue maintenance dose until methanol or ethylene glycol levels are below 10 mg/dL