What is Lortab? ​Lortab is a pain reliever made up of acetaminophen and hydrocodone. Hydrocodone is a type of opioid pain reliever. Acetaminophen, also known as Tylenol, is a less potent pain reliever that enhances hydrocodone’s effects.Lortab helps treat moderate to severe pain. You can buy Lortab online with a prescription. Important Information Taking hydrocodone can slow or stop your...